РОСБИОТЕХ
Bulletin of the Medical Institute of Continuing Education
RESTORATIVE MEDICINE

Lterature review

УДК 616.12

Included in the list of the Higher Attestation Commission
3.1.33. Rehabilitation medicine

Creative Commons License

Public license
CC BY-NC-ND 4.0

Attribution-NonCommercial-NoDerivatives 4.0 International

Creative Commons 4.0 License

MODERN APPROACHES TO EARLY DIAGNOSIS OF RADIATION-INDUCED HEART DISEASE

D.A. Andreevorcid

DOI

ABSTRACT

Background. Radiation-induced heart disease (RIHD) represents a serious late complication of radiation therapy, characterized by a wide spectrum of pathological manifestations and latent course with gradual progression from subclinical stages to manifest clinical symptoms. This review analyzes contemporary diagnostic approaches for RIHD detection at various stages of the pathological process based on domestic and international literature data.

Main content. It has been established that RIHD diagnosis requires a comprehensive multimodal approach, including imaging techniques, biomarker assessment, and functional testing. The most diagnostically valuable methods for early detection of subclinical changes are cardiac magnetic resonance imaging with late gadolinium enhancement and T1-mapping, echocardiography with assessment of left ventricular global longitudinal strain, and determination of specific biomarkers including high-sensitivity troponin T and NT-proBNP. Traditional parameters such as left ventricular ejection fraction have been shown to lack sufficient sensitivity in early stages of RIHD. Promising diagnostic directions include the use of novel radiotracers for positron emission tomography, evaluation of microRNAs as predictors of pathology development, and development of personalized surveillance algorithms.

Conclusions. Early diagnosis of RIHD is of critical importance for timely initiation of preventive measures and improvement of long-term patient prognosis, which emphasizes the necessity of implementing standardized protocols for dynamic monitoring of individuals who have undergone radiation therapy involving the cardiac region.

ABOUT AUTHOR

D.A. Andreev Cand.Sci.(Med.)

Head of the cardiology center, associate professor of the Department of Rehabilitation Medicine, Balneology and Physiotherapy, and Nursing with a course in sports medicine of A.I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency; Moscow, Russia

https://orcid.org/0009-0004-5936-827X | SPIN код: 8427-5523 | AuthorID: 887585

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KEYWORDS: radiation-induced heart disease, diagnosis, cardiac magnetic resonance imaging, echocardiography, biomarkers, cardiotoxicity

CORRESPONDENCE: Dmitriy A. Andreev, e-mail: drada_rus@mail.ru

FOR CITATIONS: Andreev D.A. Modern Approaches to Early Diagnosis of Radiation-induced Heart Disease // Bulletin of the Medical Institute of Continuing Education. — 2025. — Vol. 5, № 4. — P. 100–104. — DOI 10.36107/2782-1714_2025-5-4-100-104.

FUNDING SOURCE: The authors declare no funding for the study.

DECLARATION OF COMPETING INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

DATA AVAILABILITY STATEMENT: Data from the current study are available from the corresponding author upon reasonable request.

AUTHOR CONTRIBUTIONS

D.A. Andreev — обзор публикаций по теме статьи; написание текста рукописи.

INFORMED CONSENT FOR PUBLICATION: authors received written consent from patients for publication of medical data and photographs.

COMPLIANCE WITH ETHICAL PRINCIPLES: The study conducted complies with the standards of the Declaration of Helsinki (Declaration Helsinki) as amended in 2024. The study protocol's compliance with ethical principles was confirmed by the Local Ethics Committee Medical Institute of Continuing Education, Russian Biotechnology University (ROSBIOTECH) on (Volokolamskoe highway, 11, Moscow, Russia), protocol №12/7-4 from 28 october 2025.