РОСБИОТЕХ
Bulletin of the Medical Institute of Continuing Education
DERMATOVENEREOLOGY

Original research

УДК 616-007.17

Included in the list of the Higher Attestation Commission
3.1.23. Dermatovenereology

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Public license
CC BY-NC-ND 4.0

Attribution-NonCommercial-NoDerivatives 4.0 International

Creative Commons 4.0 License

ANIMALS IN THE EXPERIMENT AND BULLOUS EPIDERMOLYSIS IN THE CLINICAL PRACTIVE — ADAPTATION TO CHEMICAL POLLUTION

M.M. Shermatovaorcid, I.E. Torshinaorcid, M.N. Gadzhimuradovorcid, B.G. Magomedhajiyevorcid, M.T. Rasulovorcid

DOI

ABSTRACT

Background. In experimental rodent models and in human epidemiological cohorts, environmental toxins have been shown to lead to either epigenetic adaptation or adverse effects on the host.

Purpose. To evaluate the skin pathology, taking into account the adaptive capabilities of laboratory mice and patients with epidermolysis bullosa to the effects of anthropogenic factors.

Materials and methods. Two series of comparisons of white mice, the outbred SHK lines, were studied. In the second part, a clinical and anamnestic study was conducted for 7 patients with recessive dystrophic epidermolysis bullosa (RDBE).

Results. Severe destructive processes and widespread skin diseases were recorded in a group of mice that had been exposed to anthropogenic chemical agents from puberty. Animals that had been exposed to a toxic stimulus throughout their life cycle were able to adapt and normalize or significantly neutralize negative processes in the skin and its appendages.

Conclusions. The results allow to conclude that patients with RDBE respond to the new environment of ecological comfort by stabilizing the skin process. However, positive dynamics can sometimes last only for a short period of time. During dispensary management, it is necessary to take into account their individual reactions to sanatorium-resort factors.

ABOUT AUTHORS

M.M. Shermatova

Postgraduate student of the Department of Dermatology, Venereology and Cosmetology Dagestan State Medical University; Dagestan, Russia

Scopus ID: 58165379500 | Researcher ID: OAL-0523-2025 | eLibrary SPIN: 9376-8335 | AuthorID: 1228999 | https://orcid.org/0000-0002-5119-5210

I.E. Torshina Dr.Sci.(Med.)

Associate Professor, Head of the Department of Dermatovenereology, Cosmetology and Continuing Professional Education Smolensk State Medical University; Smolensk, Russia

Scopus ID 57214321337 | Researcher ID ABE-8437-202 | eLibrary SPIN 1222-6560 | Author ID 736731 | https://orcid.org/0000-0002-6562-0556;

M.N. Gadzhimuradov Dr.Sci.(Med.)

Associate Professor, Head of the Department of Dermatology, Venereology and Cosmetology Dagestan State Medical University; Dagestan, Russia

eLibrary SPIN: 4538-2170 | https://orcid.org/0000-0002-3822-6895

B.G. Magomedhajiyev Cand.Sci.(Med.)

Associate Professor of the Department of Pathological Anatomy Dagestan State Medical University; Dagestan, Russia

eLibrary SPIN: 4538-2170 | https://orcid.org/0000-0002-3822-6895

M.T. Rasulov Cand.Sci.(Med.)

Associate Professor of the Department of Pathological Anatomy Dagestan State Medical University; Dagestan, Russia

eLibrary SPIN: 2716-6918 | https://orcid.org/0000-0002-0480-9865

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KEYWORDS: chemical pollutants, experiment, rodents, ecology, epidermolysis bullosa

CORRESPONDENCE: Irina E. Torshina, e-mail: irina-torsina@mail.ru

FOR CITATIONS: Shermatova M.M., Torshina I.E., Gadzhimuradov M.N. [et al.] Animals in the Experiment and Bullous Epidermolysis in the Clinical Practice — Adaptation to Chemical Pollution // Bulletin of the Medical Institute of Continuing Education. — 2025. — Vol. 5, № 4. — P. 14–24. — DOI 10.36107/2782-1714_2025-5-4-14-24.

FUNDING SOURCE: The authors declare no funding for the study.

DECLARATION OF COMPETING INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

DATA AVAILABILITY STATEMENT: Data from the current study are available from the corresponding author upon reasonable request.

AUTHOR CONTRIBUTIONS

M.M. Shermatova, I.E. Torshina — concept and design of the study

M.M. Shermatova, M.N. Gadzhimuradov, B.G. Magomedhajiyev, M.T. Rasulov — collection and processing of material

M.M. Shermatova — statistical processing, text writing

I.E. Torshina — editing

COMPLIANCE WITH ETHICAL PRINCIPLES: The study conducted complies with the standards of the Declaration of Helsinki (Declaration Helsinki) as amended in 2024. The study protocol's compliance with ethical principles was confirmed by the Local Ethics Committee Medical Institute of Continuing Education, Russian Biotechnology University (ROSBIOTECH) on (Volokolamskoe highway, 11, Moscow, Russia), protocol №12/7-4 from 28 октября 2025 г.