РОСБИОТЕХ
Bulletin of the Medical Institute of Continuing Education
UROLOGY AND ANDROLOGY

Retrospective cohort study

УДК 616.06:614.4

Included in the list of the Higher Attestation Commission
3.1.13. Urology and andrology

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Public license
CC BY-NC-ND 4.0

Attribution-NonCommercial-NoDerivatives 4.0 International

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OPTIMIZING EMPIRICAL ANTIBACTERIAL THERAPY IN A UROLOGICAL HOSPITAL DEPARTMENT BASED ON LOCAL MICROBIOLOGICAL MONITORING ANALYSIS

I.G. Ragimovorcid, A.V. Esipovorcid, A.G. Kochetovorcid, V.A. Musailovorcid, M.A. Prokopyeva, A.A. Gritskevichorcid

DOI

ABSTRACT

Background. Due to the global spread of antibiotic resistance, the problem of selecting an appropriate antibacterial agent for empirical therapy of healthcare-associated infections in hospital conditions has become particularly urgent.. Effective prevention and treatment of postoperative infectious and inflammatory complications rely on continuous local microbiological monitoring within each medical institution.

Purpose To examine the microbiological profile of the urological department of a multidisciplinary hospital and to analyze the resistance patterns of the identified isolates to antibacterial drugs.

Materials and methods. The analysis was conducted of urine cultures results from patients who received both conservative and surgical treatment for various urological condition. A total of 1230 urine samples from 856 patients were studied. The spectrum of pathogens responsible for nosocomial urological infection was determined, and their susceptibility to antimicrobial drugs was assessed. The presence of genes of the most common carbapenemases and beta-lactamases was identified using the real-time polymerase chain reaction method.

Results. A total of 652 microbial strains were isolated from 502 positive samples. Monoculture was detected in 384 cases (76.5%) in the urine culture results. The analytical stage revealed the prevalence of gram-negative flora (69%) in the urology unit. The majority (54.1%) of the detected microorganisms belonged to the order Enterobacterales. The most common microorganism detected in hospital conditions was E. coli, found in 27.4% of the total number of strains. The second most common pathogen was gram-positive Enterococcus faecalis (23.9%).96 strains of K. pneumoniae(14.7%) were identified, and the detection of Pseudomonas aeruginosa reached 10.6%. Of the 652 isolated microorganisms, 479 (73.5%) were characterized by polyresistance.

Conclusion. The high level of antibiotic resistance in a urological hospital requires a n individualized approach to the treatment of infectious and inflammatory processes. Incorporating local microbiological monitoring data helps to optimize the initial antibiotic therapy, the success of which determines the timing and results of inpatient treatment.

ABOUT AUTHORS

I.G. Ragimov Cand.Sci.(Med.), Lieutenant colonel of the Medical Service

Head of the Urology Department of Branch №3 of National Medical Research Center for High Medical Technologies, Central Military Clinical Hospital named after A.A. Vishnevsky of the Ministry of Defense of the Russian Federation; Odintsovo, Russia

https://orcid.org/0000-0002-7679-4199

A.V. Esipov Dr.Sci.(Med.), Major General of the Medical Service, Honored Doctor of Russia

Head of National Medical Research Center for High Medical Technologies of Central Military Clinical Hospital named after A.A. Vishnevsky of the Ministry of Defense of the Russian Federation; Krasnogorsk, Russia

Professor of the Department of Surgery with a course in oncology and radiation diagnostics of Branch of Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation; Moscow, Russia

https://orcid.org/0000-0001-8239-539X

A.G. Kochetov Dr.Sci.(Med.)

Head of the Urology Center of National Medical Research Center for High Medical Technologies, Central Military Clinical Hospital named after A.A. Vishnevsky of the Ministry of Defense of the Russian Federation; Krasnogorsk, Russia

Head of the Department of Urology of Medical Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH); Moscow, Russia

https://orcid.org/0000-0003-3631-598X

V.A. Musailov Dr.Sci.(Med.), Lieutenant Colonel of the Medical Service

Head of the surgical department with operating rooms of National Medical Research Center for High Medical Technologies, Central Military Clinical Hospital named after A.A. Vishnevsky of the Ministry of Defense of the Russian Federation; Krasnogorsk, Russia

Lecturer at the Department of Emergency Surgery of Branch of Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation; Moscow, Russia

https://orcid.org/0000-0002-0168-0939

M.A. Prokopyeva

Head of the bacteriological laboratory of the laboratory department of Branch №3 of National Medical Research Center for High Medical Technologies, Central Military Clinical Hospital named after A.A. Vishnevsky of the Ministry of Defense of the Russian Federation; Odintsovo, Russia

A.A. Gritskevich Dr.Sci.(Med.)

Head of the urology department of National Medical Research Center for Surgery named after A. V. Vishnevsky of the Ministry of Health of the Russian Federation; Moscow, Russia

Professor of the Department of Urology and Operative Nephrology with a course in Oncourology of Peoples' Friendship University of Russia named after Patrice Lumumba; Moscow, Russia

https://orcid.org/0000-0002-5160-925x

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KEYWORDS: hospital microbiological monitoring, nosocomial urological infections, antibiotic resistance, antibacterial therapy

CORRESPONDENCE: Ismail G. Ragimov, e-mail: uromail@mail.ru

FOR CITATIONS: Ragimov I.G., Esipov A.V., Kochetov A.G. [et al.] Optimizing Empirical Antibacterial Therapy in a Urological Hospital Based on Local Microbiological Monitoring Analysis // Bulletin of the Medical Institute of Continuous Education. — 2025. — V. 5, No. 4. — S. 75–82. — DOI 10.36107/2782-1714_2025-5-4-75-82.

FUNDING SOURCE: The authors declare no funding for the study.

DECLARATION OF COMPETING INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

DATA AVAILABILITY STATEMENT: Data from the current study are available from the corresponding author upon reasonable request.

AUTHOR CONTRIBUTIONS

I.G. Ragimov — gathering of material, article concept development, analysis of publications on the article's topic, and formatting of the article text.

A.V. Esipov — development of the research design, scientific editing.

A.G. Kochetov — scientific editing of the article text, article concept.

V.A. Musailov — scientific editing of the article text.

M.A. Prokopyeva — bacteriological examination of the material, article concept.

A.A. Gritskevich — scientific editing of the article text.